diff --git a/packages/aws-cdk-lib/aws-ec2/lib/vpc-endpoint.ts b/packages/aws-cdk-lib/aws-ec2/lib/vpc-endpoint.ts
index d873cb30fc59a..1b343b7383d8e 100644
--- a/packages/aws-cdk-lib/aws-ec2/lib/vpc-endpoint.ts
+++ b/packages/aws-cdk-lib/aws-ec2/lib/vpc-endpoint.ts
@@ -849,11 +849,32 @@ export class InterfaceVpcEndpointAwsService implements IInterfaceVpcEndpointServ
         'servicecatalog', 'sms', 'sqs', 'states', 'sts', 'sync-states', 'synthetics', 'transcribe', 'transcribestreaming', 'transfer',
         'workspaces', 'xray'],
       'eusc-de-east-1': ['ecr.dkr', 'ecr.api', 'execute-api', 'securityhub'],
+      'us-iso-east-1': ['application-autoscaling', 'athena', 'autoscaling', 'comprehend', 'diode-messaging',
+        'diode-messaging-proxy', 'ebs', 'ec2', 'ecr.api', 'ecr.dkr', 'elasticfilesystem', 'elasticfilesystem-fips',
+        'execute-api', 'sagemaker.api', 'sagemaker.runtime', 'sns', 'sqs', 'textract', 'textract-fips', 'transcribe',
+        'workspaces'],
+      'us-iso-west-1': ['autoscaling', 'ebs', 'ec2', 'ecr.api', 'ecr.dkr', 'elasticfilesystem', 'elasticfilesystem-fips',
+        'execute-api', 'monitoring', 'sns', 'sqs', 'workspaces'],
+      'us-isob-east-1': ['application-autoscaling', 'autoscaling', 'diode-messaging', 'diode-messaging-proxy', 'ebs',
+        'ec2', 'ecr.api', 'ecr.dkr', 'elasticfilesystem', 'elasticfilesystem-fips', 'execute-api', 'sagemaker.api',
+        'sagemaker.runtime', 'sns', 'sqs', 'workspaces'],
+      'us-isob-west-1': ['ecr.api', 'ecr.dkr', 'elasticfilesystem-fips', 'execute-api'],
+      'us-isof-south-1': ['ebs', 'ecr.api', 'ecr.dkr', 'execute-api'],
+      'us-isof-east-1': ['ebs', 'ecr.api', 'ecr.dkr', 'execute-api'],
     };
     if (VPC_ENDPOINT_SERVICE_EXCEPTIONS[region]?.includes(name)) {
       switch (region) {
         case 'eusc-de-east-1':
           return 'eu.amazonaws';
+        case 'us-iso-east-1':
+        case 'us-iso-west-1':
+          return 'gov.ic.c2s';
+        case 'us-isob-east-1':
+        case 'us-isob-west-1':
+          return 'gov.sgov.sc2s';
+        case 'us-isof-south-1':
+        case 'us-isof-east-1':
+          return 'gov.ic.hci.csp';
         case 'cn-north-1':
         case 'cn-northwest-1':
           return 'cn.com.amazonaws';
diff --git a/packages/aws-cdk-lib/aws-ec2/test/vpc-endpoint.test.ts b/packages/aws-cdk-lib/aws-ec2/test/vpc-endpoint.test.ts
index 2f3d227912a81..7a39c8e1dd19c 100644
--- a/packages/aws-cdk-lib/aws-ec2/test/vpc-endpoint.test.ts
+++ b/packages/aws-cdk-lib/aws-ec2/test/vpc-endpoint.test.ts
@@ -891,6 +891,120 @@ describe('vpc endpoint', () => {
       });
     });
 
+    test.each([
+      ['us-iso-east-1', 'gov.ic.c2s'],
+      ['us-iso-west-1', 'gov.ic.c2s'],
+    ])('test vpc interface endpoint with %s prefix can be created correctly in %s', (region: string, prefix: string) => {
+      // GIVEN
+      const stack = new Stack(undefined, 'TestStack', { env: { account: '123456789012', region } });
+      const vpc = new Vpc(stack, 'VPC');
+
+      // WHEN
+      vpc.addInterfaceEndpoint('ECR Endpoint', {
+        service: InterfaceVpcEndpointAwsService.ECR,
+      });
+
+      // THEN
+      Template.fromStack(stack).hasResourceProperties('AWS::EC2::VPCEndpoint', {
+        ServiceName: `${prefix}.${region}.ecr.api`,
+      });
+    });
+
+    test.each([
+      ['us-iso-east-1'],
+      ['us-iso-west-1'],
+    ])('test vpc interface endpoint without gov.ic.c2s prefix can be created correctly in %s', (region: string) => {
+      // GIVEN
+      const stack = new Stack(undefined, 'TestStack', { env: { account: '123456789012', region } });
+      const vpc = new Vpc(stack, 'VPC');
+
+      // WHEN
+      vpc.addInterfaceEndpoint('ECS Endpoint', {
+        service: InterfaceVpcEndpointAwsService.ECS,
+      });
+
+      // THEN
+      Template.fromStack(stack).hasResourceProperties('AWS::EC2::VPCEndpoint', {
+        ServiceName: `com.amazonaws.${region}.ecs`,
+      });
+    });
+
+    test.each([
+      ['us-isob-east-1', 'gov.sgov.sc2s'],
+      ['us-isob-west-1', 'gov.sgov.sc2s'],
+    ])('test vpc interface endpoint with %s prefix can be created correctly in %s', (region: string, prefix: string) => {
+      // GIVEN
+      const stack = new Stack(undefined, 'TestStack', { env: { account: '123456789012', region } });
+      const vpc = new Vpc(stack, 'VPC');
+
+      // WHEN
+      vpc.addInterfaceEndpoint('ECR Endpoint', {
+        service: InterfaceVpcEndpointAwsService.ECR,
+      });
+
+      // THEN
+      Template.fromStack(stack).hasResourceProperties('AWS::EC2::VPCEndpoint', {
+        ServiceName: `${prefix}.${region}.ecr.api`,
+      });
+    });
+
+    test.each([
+      ['us-isob-east-1'],
+      ['us-isob-west-1'],
+    ])('test vpc interface endpoint without gov.sgov.sc2s prefix can be created correctly in %s', (region: string) => {
+      // GIVEN
+      const stack = new Stack(undefined, 'TestStack', { env: { account: '123456789012', region } });
+      const vpc = new Vpc(stack, 'VPC');
+
+      // WHEN
+      vpc.addInterfaceEndpoint('ECS Endpoint', {
+        service: InterfaceVpcEndpointAwsService.ECS,
+      });
+
+      // THEN
+      Template.fromStack(stack).hasResourceProperties('AWS::EC2::VPCEndpoint', {
+        ServiceName: `com.amazonaws.${region}.ecs`,
+      });
+    });
+
+    test.each([
+      ['us-isof-south-1', 'gov.ic.hci.csp'],
+      ['us-isof-east-1', 'gov.ic.hci.csp'],
+    ])('test vpc interface endpoint with %s prefix can be created correctly in %s', (region: string, prefix: string) => {
+      // GIVEN
+      const stack = new Stack(undefined, 'TestStack', { env: { account: '123456789012', region } });
+      const vpc = new Vpc(stack, 'VPC');
+
+      // WHEN
+      vpc.addInterfaceEndpoint('ECR Endpoint', {
+        service: InterfaceVpcEndpointAwsService.ECR,
+      });
+
+      // THEN
+      Template.fromStack(stack).hasResourceProperties('AWS::EC2::VPCEndpoint', {
+        ServiceName: `${prefix}.${region}.ecr.api`,
+      });
+    });
+
+    test.each([
+      ['us-isof-south-1'],
+      ['us-isof-east-1'],
+    ])('test vpc interface endpoint without gov.ic.hci.csp prefix can be created correctly in %s', (region: string) => {
+      // GIVEN
+      const stack = new Stack(undefined, 'TestStack', { env: { account: '123456789012', region } });
+      const vpc = new Vpc(stack, 'VPC');
+
+      // WHEN
+      vpc.addInterfaceEndpoint('ECS Endpoint', {
+        service: InterfaceVpcEndpointAwsService.ECS,
+      });
+
+      // THEN
+      Template.fromStack(stack).hasResourceProperties('AWS::EC2::VPCEndpoint', {
+        ServiceName: `com.amazonaws.${region}.ecs`,
+      });
+    });
+
     test('test codeartifact vpc interface endpoint in us-west-2', () => {
       // GIVEN
       const stack = new Stack(undefined, 'TestStack', { env: { account: '123456789012', region: 'us-west-2' } });