Merge pull request #238 from monarch-initiative/weekly-compliance-2026-02-03-GeneralizedAnxietyDisorder

🤖 Weekly Compliance Fixes (2026-02-03): Generalized Anxiety Disorder Cell Types

Author: caufieldjh

kb/disorders/Generalized_Anxiety_Disorder.yaml

@@ -13,6 +13,11 @@ pathophysiology:
     Exaggerated amygdala response to perceived threats leads to
     excessive fear and anxiety. Reduced prefrontal cortex regulation
     of amygdala activity.
+  cell_types:
+  - preferred_term: Amygdala Pyramidal Neuron
+    term:
+      id: CL:4023110
+      label: amygdala pyramidal neuron
   biological_processes:
   - preferred_term: Fear Response
     term:
@@ -27,6 +32,11 @@ pathophysiology:
   description: >
     Reduced GABAergic inhibition contributes to neuronal hyperexcitability
     and anxiety. Benzodiazepines enhance GABA function.
+  cell_types:
+  - preferred_term: GABAergic Interneuron
+    term:
+      id: CL:0011005
+      label: GABAergic interneuron
   biological_processes:
   - preferred_term: GABAergic Transmission
     term:
@@ -49,6 +59,11 @@ pathophysiology:
   description: >
     Altered serotonin signaling, particularly in raphe-prefrontal
     circuits, contributes to anxiety. SSRIs are first-line treatment.
+  cell_types:
+  - preferred_term: Serotonergic Neuron
+    term:
+      id: CL:0000850
+      label: serotonergic neuron
   biological_processes:
   - preferred_term: Serotonin Signaling
     term:
@@ -85,6 +100,11 @@ pathophysiology:
   description: >
     Elevated norepinephrine activity in locus coeruleus contributes
     to hyperarousal and somatic symptoms of anxiety.
+  cell_types:
+  - preferred_term: Noradrenergic Neuron
+    term:
+      id: CL:0008025
+      label: noradrenergic neuron
 - name: Oxidative Stress
   description: >
     Increased oxidative stress markers and reduced antioxidant enzyme
@@ -104,6 +124,15 @@ pathophysiology:
     DNA methylation changes in anxiety-related genes, particularly in
     monocytes and granulocytes. Methylation sites identified in genes
     involved in neurogenesis and fear memory.
+  cell_types:
+  - preferred_term: Monocyte
+    term:
+      id: CL:0000576
+      label: monocyte
+  - preferred_term: Granulocyte
+    term:
+      id: CL:0000094
+      label: granulocyte
   evidence:
   - reference: PMID:37542162
     supports: SUPPORT