**What is new on github version, but not yet in the release?** - [x] 06.03.2023: Enabled remote fastq download from anonymous ftp (e.g., ENA,...) - [x] 10.03.2023: Added alignment trimming with BamUtil - [x] 10.05.2023: BUG: PE sample file: Corrected that SE files are accepted. - [x] 12.12.2023: BUG: Parameter 'params_adapterremoval' in rule 'adapterremoval_se' misspelled. - [x] 02.02.2024: Implemented GLIMPSE2 and adapted GLIMPSE1 parameters. **TODO** - [ ] Implement preseq