Add Wissler syndrome #200
Add Wissler syndrome #200
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Claude finished @caufieldjh's task —— View job PR Review: Add Wissler syndromeReview Checklist
🔍 Code Quality ReviewOverall Assessment: HIGH QUALITY ✅ 📋 Detailed Findings✅ Strengths
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Claude finished @caufieldjh's task —— View job PR Review: Add Wissler syndromeReview Checklist
🔍 Code Quality ReviewOverall Assessment: HIGH QUALITY ✅ 📋 Detailed Findings✅ Strengths
|
|
Claude finished @caufieldjh's task —— View job PR Review: Add Wissler syndromeReview Checklist
🔍 Code Quality ReviewOverall Assessment: HIGH QUALITY ✅ 📋 Detailed Findings✅ Strengths
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| - name: Recurrent high fever | ||
| category: Systemic | ||
| frequency: FREQUENT | ||
| phenotype_term: |
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should have qualifiers for recurrent + high
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| phenotype_term: | |
| - name: Recurrent high fever | |
| category: Systemic | |
| frequency: FREQUENT | |
| phenotype_term: | |
| preferred_term: Recurrent fever | |
| term: | |
| id: HP:0001954 | |
| label: Recurrent fever | |
| qualifiers: | |
| - HIGH | |
| evidence: |
Using HP:0001954 "Recurrent fever" which better captures the recurrent nature, plus a HIGH qualifier for fever severity. This is a more specific term than HP:0001945 "Fever" and includes the recurrence semantics.
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do not apply suggestion. The suggested replacement is fine but the placement is wrong. See #197
| - name: Polymorphous exanthema | ||
| category: Dermatological | ||
| frequency: FREQUENT | ||
| phenotype_term: |
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this is a bit more general than the actual term
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| phenotype_term: | |
| - name: Polymorphous exanthema | |
| category: Dermatological | |
| frequency: FREQUENT | |
| phenotype_term: | |
| preferred_term: Exanthem | |
| term: | |
| id: HP:4000054 | |
| label: Exanthem | |
| evidence: |
Using HP:4000054 "Exanthem" which is defined as "A widespread rash" - more specific than the generic "Skin rash" (HP:0000988). The polymorphous nature can be captured in the name field while the term anchors it to the concept of a widespread eruption.
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do not apply suggestion. The suggested replacement is fine but the placement is wrong. See #197
| supports: SUPPORT | ||
| snippet: "The authors report a case with chronic pericardo-myocarditis progressing over a 7 year period to refractory congestive cardiac failure." | ||
| explanation: The case report documents progression to refractory congestive heart failure. | ||
| biochemical: |
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The Biochemical class in the current schema does not have a biomarker_term or measurement_term slot. However, MAXO does have relevant terms:
MAXO:0035093- erythrocyte sedimentation rate measurementMAXO:0000551- C-reactive protein biomarker assessment
Options:
- Add these MAXO terms to the disease-level notes/context until the schema supports biomarker terms
- Propose a schema enhancement to add a
measurement_termslot to the Biochemical class - Keep as-is with the existing freetext name field
The existing entries are correctly capturing the presence/elevation status; adding formal term bindings would require schema modification.
| snippet: "Blood sample analysis revealed high levels of CRP (42.9 mg/dL, normal: 0–0.3), erythrocyte sedimentation rate (113 mm/h normal: 2–20)" | ||
| explanation: The case report documents markedly elevated CRP as part of the inflammatory syndrome. | ||
| progression: | ||
| - phase: Onset |
| supports: SUPPORT | ||
| snippet: "Zunächst haben nur die Pädiater die Krankheit gesehen, neuerdings sind aber auch Fälle bei Erwachsenen bekanntgegeben worden." | ||
| explanation: The abstract notes that early reports were pediatric, with adult cases reported later. | ||
| - phase: Chronic course |
| supports: SUPPORT | ||
| snippet: "The long-term evolution is marked by recurrent febrile exacerbations, sometimes complicated by pericardo-myocarditis which usually resolves without sequellae." | ||
| explanation: The abstract summarizes recurrent febrile exacerbations and possible cardiac complications over time. | ||
| epidemiology: |
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these are slightly odd entries for epidemiology
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These epidemiology entries describe historical publication patterns rather than population-level disease metrics. Options:
- Move to notes section - These are meta-observations about literature rather than true epidemiology
- Keep but rename - Change to "Historical context" or similar if there is a suitable slot
- Remove - If this information does not fit the schema intent
The entries would better fit a "historical_context" or "notes" field since they describe where the disease was recognized/published rather than incidence/prevalence data.
| treatments: | ||
| - name: Nonsteroidal anti-inflammatory drugs | ||
| description: NSAIDs can reduce fever and inflammatory symptoms. | ||
| treatment_term: |
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this could be improved
- there is specific term in MAXO for NSAID class
- the therapy is actually combination therapy. We recently started introducing some patterns for this with the latest batch of cancer terms but this is not well documented yet
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| treatment_term: | |
| - name: Nonsteroidal anti-inflammatory drugs | |
| description: NSAIDs can reduce fever and inflammatory symptoms. | |
| treatment_term: | |
| preferred_term: NSAID therapy | |
| term: | |
| id: MAXO:0000221 | |
| label: NSAID therapy | |
| evidence: |
MAXO:0000221 "NSAID therapy" is the appropriate class-level term for NSAID treatment. This avoids needing the complex pharmacotherapy+qualifier pattern and directly anchors to the specific treatment modality. The specific agent (naproxen) is mentioned in the evidence.
| supports: SUPPORT | ||
| snippet: "A combination of nonsteroidal anti-inflammatory drugs and steroids achieved complete remission." | ||
| explanation: The case report documents remission with NSAID therapy. | ||
| - name: Corticosteroids |
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this is a bit of a mishmash of things at different levels of granularity and the evidence doesn't seem to be precisely supporting what is said.
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The entry mixes a class-level treatment term (corticosteroids) with specific drug evidence (prednisolone) and combination therapy evidence. Suggestions:
- Use MAXO class term:
MAXO:0000640"corticosteroid agent therapy" is more appropriate than the generic pharmacotherapy+qualifier pattern - Clarify scope: The evidence shows steroids used in combination (NSAID+steroid, azathioprine+steroid) - either split by combination regimen or note this is a component of combination therapy
- name: Corticosteroids
description: Systemic corticosteroids (e.g., prednisolone) used as part of combination regimens to control inflammation.
treatment_term:
preferred_term: corticosteroid agent therapy
term:
id: MAXO:0000640
label: corticosteroid agent therapyThe evidence references combination regimens; the other treatment entries can cross-reference or we can consolidate into combination entries per the reviewer's later comments.
| explanation: The case report notes complete remission with steroids plus NSAIDs. | ||
| - reference: PMID:1210460 | ||
| supports: SUPPORT | ||
| snippet: "In the present case the disease could successfully be controlled using imuran in combination with corticosteroids." |
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Agreed - the evidence for dapsone clearly shows it was used as part of a 3-drug combination (naproxen + dapsone + prednisolone). Options:
- Restructure as combination therapy entry: Create a single treatment entry representing the combination regimen
- Add explicit notes: Note in description that dapsone was used as part of combination therapy with NSAIDs and corticosteroids
- Cross-reference: Add a notes field indicating "Used in combination with corticosteroids and NSAIDs"
The current schema may not have a formal "combination_therapy" slot. If this is a pattern seen across cancer entries, we could adopt that pattern here as well.
| supports: SUPPORT | ||
| snippet: "In the present case the disease could successfully be controlled using imuran in combination with corticosteroids." | ||
| explanation: The abstract indicates corticosteroids were part of successful therapy. | ||
| - name: Dapsone |
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I think this is fine but better to be explicit about combos
| supports: SUPPORT | ||
| snippet: "A combination of naproxen, dapsone, and prednisolone therapy resulted in significant improvement of the patient’s arthralgias and rash." | ||
| explanation: The case report documents improvement with dapsone as part of combination therapy. | ||
| - name: Azathioprine |
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Agreed - the azathioprine entry should clearly indicate combination therapy with corticosteroids. The evidence states "imuran in combination with corticosteroids."
Suggested restructure:
- name: Azathioprine plus corticosteroids
description: Immunosuppressive combination therapy using azathioprine with corticosteroids for disease control.
treatment_term:
preferred_term: immune suppressant agent therapy
term:
id: MAXO:0000297
label: immune suppressant agent therapy
notes: Combination regimen - azathioprine (imuran) with corticosteroidsOr if MAXO has a specific combination therapy term, that would be preferable.
cmungall
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cmungall
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mostly good but needs some work on the treatments. I think better to say less with controlled terms for now, focus on the strings not things
Editorial Review Bot SummaryPR Scanned: #200 (Add Wissler syndrome)
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